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Z-YVAD-FMK

Cat. No. M6233
Z-YVAD-FMK Structure
Size Price Availability Quantity
5mg USD 450 In stock
10mg USD 820 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 630.66
Formula C31H39FN4O9
CAS Number
Purity >98%
Solubility 31.6mg/mL in DMSO
Storage at -20°C
Customer Product Validations & Biological Datas
Source Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK
Method western blotting
Cell Lines GBM cells
Concentrations 20 μM
Incubation Time 3 h
Results To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death.
Rating
References

IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.
Gicquel T, et al. FASEB J. 2015 Oct;29(10):4162-73. PMID: 26116704.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, et al. Nat Immunol. 2014 Aug;15(8):727-37. PMID: 24952505.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Z-YVAD-FMK supplier, Caspase, inhibitors

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