Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
|Source||Cell Physiol Biochem (2018). Figure 3. Z-VAD-FMK|
|Cell Lines||GBM cells|
|Incubation Time||3 h|
|Results||To examine whether RA-induced apoptosis was caspase-dependent, we introduced the pan-caspase inhibitor z-VAD-fmk. As shown in Fig. 3D, combined treatment with z-VAD-fmk rescued RA-induced cell death.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||31.6mg/mL in DMSO|
IL-1β production is dependent on the activation of purinergic receptors and NLRP3 pathway in human macrophages.
Gicquel T, et al. FASEB J. 2015 Oct;29(10):4162-73. PMID: 26116704.
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, et al. Nat Immunol. 2014 Aug;15(8):727-37. PMID: 24952505.
|Related Caspase Products|
CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
Z-LEED-FMK is caspase-13 inhibitor.
Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM.
Emricasan is a potent irreversible pan-caspase inhibitor.
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