Q-VD-OPh is a potent pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Source||J Clin Invest (2018). Figure 1. Q-VD-OPh|
|Method||cell proliferation assay|
|Cell Lines||CD3+CD8+ T cells|
|Incubation Time||24 h|
|Results||Our results showed that Q-VD-OPH inhibits spontaneous cell death of CD4+ T cells isolated from peripheral lymph nodes (LNs) (axillary and inguinal) and spleen of SIVinfected RMs|
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