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Ac-FLTD-CMK

Cat. No. M10774
Ac-FLTD-CMK  Structure
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Biological Activity

Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against caspases-1 (IC50 of 46.7 nM), caspases-4 (IC50 of 1.49 μM), caspases-5 (IC50 of 329 nM), and caspases-11 , but not the apoptotic caspases such as caspase-3.

Chemical Information
Molecular Weight 569.05
Formula C26H37ClN4O8
CAS Number 2376255-48-8
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ning Li, et al. Pharmacol Res. Pathway network of pyroptosis and its potential inhibitors in acute kidney injury

[2] Brandon E Burdette, et al. Acta Pharm Sin B. Gasdermin D in pyroptosis

[3] Pengfei Wang, et al. Neuroreport. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury

[4] X X Tian, et al. Int Endod J. NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation

[5] Jie Yang, et al. Proc Natl Acad Sci U S A. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

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  Catalog
Abmole Inhibitor Catalog




Keywords: Ac-FLTD-CMK supplier, Caspase, inhibitors, activators


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