Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
|Source||Oncotarget (2018). Figure 5. Z-DEVD-FMK|
|Cell Lines||CEM/VLB100 cells|
|Incubation Time||24 h|
|Results||CEM/VLB100 cells were treated with CCB in the presence of Z-DEVD-FMK, and cell death was determined by flow cytometry. Z-DEVDFMK was not able to prevent CCB-induced apoptotic cell death, indicating the existence of a caspaseindependent type of cell death.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Related Caspase Products|
Ac-DEVD-CHO is a specific inhibitor of Caspase-3 with a Ki value of 230 pM.
CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.
Z-LEED-FMK is caspase-13 inhibitor.
Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
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