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Z-DEVD-FMK

Cat. No. M3134
Z-DEVD-FMK Structure
Synonym:

Caspase-3 Inhibitor

Size Price Availability Quantity
1mg USD 90 In stock
5mg USD 280 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

Customer Product Validations & Biological Datas
Source Oncotarget (2018). Figure 5. Z-DEVD-FMK
Method FACS
Cell Lines CEM/VLB100 cells
Concentrations 25 μM
Incubation Time 24 h
Results CEM/VLB100 cells were treated with CCB in the presence of Z-DEVD-FMK, and cell death was determined by flow cytometry. Z-DEVDFMK was not able to prevent CCB-induced apoptotic cell death, indicating the existence of a caspaseindependent type of cell death.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 668.66
Formula C30H41FN4O12
CAS Number 210344-95-9
Purity >98%
Solubility DMSO
Storage at -20°C
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Z-YVAD-FMK

Z-YVAD-FMK is a synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies.

Z-LEED-FMK

Z-LEED-FMK is caspase-13 inhibitor.

Z-VAD(OH)-FMK

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Z-DEVD-FMK, Caspase-3 Inhibitor supplier, Caspase, inhibitors

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