Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.It Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis.
Cell Death Dis. 2024 Feb;15(2):129.
Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression
Apoptosis Activator 2 purchased from AbMole
| Molecular Weight | 306.14 |
| Formula | C15H9Cl2NO2 |
| CAS Number | 79183-19-0 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Su-Been Lee, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A 2
[4] Vitaliy O Kaminskyy, et al. Free radicals in cross talk between autophagy and apoptosis
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