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Cat. No. M3026
Sorafenib Structure

BAY 43-9006

Size Price Availability Quantity
100mg USD 60 In stock
1g USD 120 In stock
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Quality Control
Biological Activity

Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

Cell Experiment
Cell lines PLC/PRF/5, Hep3B, HepG2, HuH7
Preparation method PLC/PRF/5, Hep3B, HepG2 and HuH7 Cells were seeded in 96-well plates (3,000 cells/well) and incubated overnight for attachment, and were then treated with indicated agents in 10% FBS supplemented medium for 72 hours. The medium was replaced with MTT (0.5 mg/ml) at 37°C for 2 hours. After removal of medium, the cells were lysed with 200 μl per well dimethyl sulfoxide (DMSO), and absorbance at 570 nm was measured and the values of 50% inhibition concentration (IC50) for each drug were determined.
Concentrations 0, 0.25, 0.5,1, 2 µM
Incubation time 72 hours
Animal Experiment
Animal models PLC/PRF/5 xenograft model in female athymic nude mice of 4–5 weeks of age
Formulation Dissolved in Cremophor EL/ethanol (50:50; Sigma Cremophor EL, 95% ethanol) at 4 × concentration.
Dosages 60 mg/kg
Administration Po, qd
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 464.82
Formula C21H16ClF3N4O3
CAS Number 284461-73-0
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Phytomedicine (2015). Figure 1. Sorafenib was purchased from AbMole (Shanghai, China)
Method Cell viability was determined by MTT assay
Cell Lines HCC HepG2
Concentrations 0~100 µM
Incubation Time 24, 48, 72 hours
Results PPI dose- and time-dependently inhibited the proliferation of HepG2 cells, with IC50 values of 1.047 ± 0.376µM within 24 h. Sorafenib was used as a positive control in HepG2 cells.
Product Citations

Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma
Xiufeng Jiang, et,al. Oncotarget, 2015,6;14.

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Abmole Inhibitor Catalog 2017

Keywords: Sorafenib, BAY 43-9006 supplier, Raf, inhibitors

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