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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M8886 | RAF709 | RAF709 is a novel Raf kinase inhibitor with IC50 values of 0.4 and 1.5 nM for c-Raf and b-Raf, respectively. |
| M5327 | L-779450 | L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. |
| M3026 | Sorafenib | Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. |
| M2927 | PF-04880594 | PF-04880594 is a RAF inhibitor for BRAF/BRAFV599E and c-RAF with IC50 of 0.19 nM/0.13 nM and 0.39 nM, >100-fold selectivity over CSNK1, JNK2/3 and p38. |
| M2813 | LGX818 | LGX818 is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. |
| M2745 | GW5074 | GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted. |
| M2319 | AZ628 | AZ628 is a potent inhibitor for wild-type CRAF and BRAF V600E with IC50 of 29 nM and 34 nM, respectively. |
| M2235 | TAK-632 | TAK-632 is a potent and selective pan-RAF inhibitor. |
| M2090 | MLN2480 | MLN2480 (BIIB-024) is an oral, selective pan-Raf kinase inhibitor. |
| M2045 | CEP-32496 | CEP-32496 is a potent orally active BRAF inhibitor with IC50 of 14 nM. |
| M1988 | Dabrafenib | Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor. |
| M1863 | RAF265 | RAF265 is a novel, orally bioavailable dual inhibitor of RAF kinase and VEGFR2. |
| M1855 | Dabrafenib Mesylate | Dabrafenib (GSK2118436) is a selective, orally bioavailable inhibitor of Mutant B-raf (BRAF) protein kinase with potential antineoplastic activity. |
| M1818 | ZM 336372 | ZM 336372 is a potent, selective ATP-competitive inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). |
| M1783 | SB590885 | SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively. |
| M1774 | PLX-4720 | PLX-4720 is a selective BRAFV600E inhibitor with the IC50 values of 160 nM and 130 nM for B-Raf and BRK respectively. |
| M1761 | PLX4032 | PLX4032 (Vemurafenib, RG7204, RO5185426 and Zelboraf) is a highly selective B-Raf enzyme inhibitor with an IC50 of 44 nM against V600E-mutant BRAF. |
| M1714 | GDC-0879 | GDC-0879 is a potent and selective B-Raf kinase inhibitor with an EC50 of 0.75 µM. |
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