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Abmole Inhibitor Catalog 2017

Raf

Inhibitors

Cat.No.  Name Information
M5327 L-779450 L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
M3026 Sorafenib Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
M2927 PF-04880594 PF-04880594 is a RAF inhibitor for BRAF/BRAFV599E and c-RAF with IC50 of 0.19 nM/0.13 nM and 0.39 nM, >100-fold selectivity over CSNK1, JNK2/3 and p38.
M2813 LGX818 LGX818 is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM.
M2745 GW5074 GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted.
M2319 AZ628 AZ628 is a potent inhibitor for wild-type CRAF and BRAF V600E with IC50 of 29 nM and 34 nM, respectively.
M2235 TAK-632 TAK-632 is a potent and selective pan-RAF inhibitor.
M2090 MLN2480 MLN2480 (BIIB-024) is an oral, selective pan-Raf kinase inhibitor.
M2045 CEP-32496 CEP-32496 is a potent orally active BRAF inhibitor with IC50 of 14 nM.
M1988 Dabrafenib Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M1863 RAF265 RAF265 is a novel, orally bioavailable dual inhibitor of RAF kinase and VEGFR2.
M1855 Dabrafenib Mesylate Dabrafenib (GSK2118436) is a selective, orally bioavailable inhibitor of Mutant B-raf (BRAF) protein kinase with potential antineoplastic activity.
M1818 ZM 336372 ZM 336372 is a potent, selective ATP-competitive inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf).
M1783 SB590885 SB590885 is a selective small-molecule inhibitor of the B-Raf kinase and Ki values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively.
M1774 PLX-4720 PLX-4720 is a selective BRAFV600E inhibitor with the IC50 values of 160 nM and 130 nM for B-Raf and BRK respectively.
M1761 PLX4032 PLX4032 (Vemurafenib, RG7204, RO5185426 and Zelboraf) is a highly selective B-Raf enzyme inhibitor with an IC50 of 44 nM against V600E-mutant BRAF.
M1714 GDC-0879 GDC-0879 is a potent and selective B-Raf kinase inhibitor with an EC50 of 0.75 µM.

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