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B-Raf-IN-1

Cat. No. M8897
B-Raf-IN-1 Structure
Synonym:

MDK36057

Size Price Availability
5mg USD 360 4-7 Days
10mg USD 525 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

B-Raf-IN-1 (MDK36057) is a highly potent and selective B-Raf inhibitor with IC50 of 24 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 515.54
Formula C29H24F3N5O
CAS Number 950736-05-7
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C
References

Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. PMID: 19864136.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: B-Raf-IN-1, MDK36057 supplier, Raf, inhibitors

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