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 About 30 results found for searched term "Raf" (0.043 seconds)

Cat.No.  Name Target
M1669 Regorafenib VEGFR/PDGFR
BAY 73-4506
Regorafenib (BAY 73-4506) is a novel oral multikinase inhibitor of c-KIT, VEGFR2, B-Raf with IC50s of 17, 40 and 69 nM respectively.
M1761 Vemurafenib (PLX4032) Raf
RG7204; RO5185426
Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy.
M1827 Sorafenib Tosylate VEGFR/PDGFR
BAY 43-9006,Nexavar
Sorafenib (BAY 43-9006) Tosylate is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
M1855 Dabrafenib Mesylate Raf
GSK-2118436B
Dabrafenib (GSK2118436) is a selective, orally bioavailable inhibitor of Mutant B-raf (BRAF) protein kinase with potential antineoplastic activity.
M1863 RAF265 Raf
CHIR-265
RAF265 is a novel, orally bioavailable dual inhibitor of RAF kinase and VEGFR2.
M1934 Tacrolimus (FK506) Autophagy
Fujimycin; FR900506; Prograf
Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. *The compound is unstable in solutions, freshly prepared is recommended
M1988 Dabrafenib Raf
GSK2118436
Dabrafenib (free base) (GSK2118436A) is a V600 mutant BRAF-specific inhibitor.
M2045 CEP-32496 Raf
RXDX-105; Agerafenib
CEP-32496 is a potent orally active BRAF inhibitor with IC50 of 14 nM.
M2090 MLN2480 Raf
BIIB-024; Tovorafenib
MLN2480 is an orally active, CNS-permeable, highly selective inhibitor of type II RAF kinase that inhibits both monomeric (class I mutant) and dimeric forms of RAF and does not cause aberrant activation of the MAPK pathway caused by type I RAF inhibitors. In addition, MLN2480 inhibits the growth of tumors harboring BRAF fusions or BRAF V600 mutations and can be used in studies related to gliomas.
M2813 LGX818 Raf
Encorafenib
LGX818 is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM.
M3026 Sorafenib (BAY 43-9006) Raf
BAY 43-9006
Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
M5005 Regorafenib Monohydrate VEGFR/PDGFR
BAY 73-4506 monohydrate
Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
M5059 Furafylline Cytochrome P450 (e.g. CYP17)
Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM.
M5925 Regorafenib HCl VEGFR/PDGFR
BAY73-4506 hydrochloride
Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
M5950 Sarafloxacin HCl Antibiotic
A-56620 HCl
Sarafloxacin HCl is a hydrochloride salt form of sarafloxacin which is a quinolone antibiotic drug with IC50 of 0.96 μg/L.
M8459 CD40-TRAF6 signaling inhibitor Others
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40.
M8885 Rafoxanide Anti-infection
Rafoxanide is a novel allosteric inhibitor of SPAK and OSR1.
M8886 RAF709 Raf
RAF709 is a novel Raf kinase inhibitor with IC50 values of 0.4 and 1.5 nM for c-Raf and b-Raf, respectively.
M8897 B-Raf-IN-1 Raf
MDK36057
B-Raf-IN-1 (MDK36057) is a potent b-Raf inhibitor with IC50 of 24 nM.
M9492 B-Raf inhibitor 1 Raf
ABM-0403
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK, respectively.
M9792 Sarafotoxin S6c Endothelin Receptor
Sarafotoxin S6c is a highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).
M9913 Mineral oil Adjuvants
paraffin oil; Waste mineral oil
Mineral oil is an emollient cleanser and demulsifier of dirt trapped in pores, used as adjuvant.
M10152 Naporafenib Raf
LXH254
Naporafenib (also known as LXH254) is an orally available inhibitor of C-Raf and B-Raf with potential antineoplastic activity.
M10373 CB-103 Notch
CB103; Limantrafin
CB-103 is a first-in-class, orally active inhibitor of the Notch transcription activation complex. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis.
M10475 Lifirafenib (BGB-283) Raf
Beigene-283
Lifirafenib (BGB-283) is a novel potent and selective RAF Kinase and EGFR inhibitor with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
M10484 Nalfurafine hydrochloride Opioid Receptor
TRK-820 hydrochloride
Nalfurafine hydrochloride (TRK-820 hydrochloride) is a potent selective and orally active kappa opioid receptor (KOR) agonist.
M13929 Vercirnon CCR
GSK-1605786; CCX282-B; Traficet-EN
Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9.
M13930 Vercirnon sodium CCR
GSK-1605786 sodium; CCX282-B sodium; Traficet-EN sodium
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9.
M16672 Sophoraflavanone G Apoptosis
Kushenol F
Sophoraflavanone G induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways. Sophoraflavanone G (Kushenol F) shows anti-tumor and anti-inflammatory properties.
M16740 Putraflavone Flavonoids
Putraflavone



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