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TRAF-STOP inhibitor 6877002 is a small molecule that binds to TRAF6, blocking interactions with CD40. TRAF-STOP inhibitor 6877002 inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. TRAF-STOP inhibitor 6877002 reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.
| Molecular Weight | 251.32 |
| Formula | C17H17NO |
| CAS Number | 433249-94-6 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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