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CD40-TRAF6 signaling inhibitor

Cat. No. M8459

All AbMole products are for research use only, cannot be used for human consumption.

CD40-TRAF6 signaling inhibitor Structure

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Quality Control & Documentation
Biological Activity

CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

Chemical Information
Molecular Weight 251.32
Formula C17H17NO
CAS Number 433249-94-6
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lena Bosch, et al. Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure

[2] Suzanne A B M Aarts, et al. Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

[3] Jose-Andres C Portillo, et al. Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling

[4] Jose-Andres C Portillo, et al. Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells

[5] Antonios Chatzigeorgiou, et al. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

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Keywords: CD40-TRAF6 signaling inhibitor supplier, inhibitors, activators

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