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Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM. Furafylline had either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P450IID1, P450IIC, P450IIA.
| Molecular Weight | 260.25 |
| Formula | C12H12N4O3 |
| CAS Number | 80288-49-9 |
| Solubility (25°C) | DMSO >10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cytochrome P450 (e.g. CYP17) Products |
|---|
| Musk ketone
Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. |
| MS-PPOH
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor. |
| (R)-Mephenytoin
(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. |
| (3S,5S)-Atorvastatin
(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. |
| (3S,5S)-Atorvastatin sodium salt
(3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin. |
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Products are for research use only. Not for human use. We do not sell to patients.
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