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Ketoconazole is an imidazole-containing small molecule inhibitor of cytochrome P-450. It is an inhibitor of CYP17A1, CYP3A4 and CYP3A5. Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole also inhibits TXA Synthase (thromboxane synthetase) and 5-LO (5-lipoxygenase) activity. Ketoconazole induces a decrease of the number of cells in S phase and a corresponding increase of the percentage of cells in Go-G1 in HT29-S-B6 cells. Ketoconazole (25 mg/kg, i.p.) significantly decreased plasma corticosterone and reduced low dose cocaine self-administration without affecting food-reinforced responding. Ketoconazole is currently in a phase 2 clinical trial with Prostate Cancer.
| Molecular Weight | 531.43 |
| Formula | C26H28Cl2N4O4 |
| CAS Number | 65277-42-1 |
| Solubility (25°C) | DMSO 3 mg/mL Ethanol 7 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cytochrome P450 (e.g. CYP17) Products |
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| Musk ketone
Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. |
| MS-PPOH
MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor. |
| (R)-Mephenytoin
(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. |
| (3S,5S)-Atorvastatin
(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. |
| (3S,5S)-Atorvastatin sodium salt
(3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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