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Cytochrome P450 (e.g. CYP17) Cytochrome P450 (e.g. CYP17)

Cat.No.  Name Information
M3326 Memantine hydrochloride Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
M2079 Chrysin Chrysin is a naturally occurring flavone chemically extracted from the passion flowers Passiflora caerulea.
M55337 (S)-Mephenytoin (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism.
M45067 Abiraterone decanoate Abiraterone decanoate is a novel, long-acting Abiraterone precursor compound that also exhibits high CYP17 cleavage enzyme inhibition selectivity for prostate cancer related studies.
M42311 Opevesostat Opevesostat is a cholesterol side-chain cleavage enzyme (CYP11A1) inhibitor.
M40620 TP0472993 TP0472993 is a novel, orally active, selective inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis that inhibits the production of 20-HETE, thereby reducing the ERK1/2 and STAT3 signaling pathways, and ultimately inhibiting the progression of renal fibrosis. It can be used in studies related to chronic kidney disease (CKD).
M22269 1-Ethynylnaphthalene 1-Ethynylnaphthalene
M21184 Soticlestat Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, orally active inhibitor of cholesterol 24-hydroxylase (CH24H), which is used in the study of epilepsy syndromes.
M21085 Pregnenolone 16α-carbonitrile Pregnenolone 16α-carbonitrile is a derivative of pregnendione that functions as an agonist of the rodent pregnane X receptor (PXR). pregnenolone 16α-carbonitrile is a synthetic steroid that induces expression of cytochrome P450 3A. Pregnenolone 16α-carbonitrile exhibits greater tolerance to subsequent stress injury.
M19949 Phloracetophenone Phloracetophenone, or 2,4,6-trihydroxyacetophenone (THA), the aglycone component of phloracetophenone glucoside, is a naturally occurring compound obtained from the rhizome of Curcuma comosa (Family Zingiberaceae).
M19353 Fraxinol Fraxinol is isolated from Lobelia chinensis.
M14314 N-Nornuciferine N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively.
M14311 Cecropin B Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic.
M14310 Bergamottin Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.
M11528 Naringin Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
M11176 Tebuconazole Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively.
M11164 SDZ285428 SDZ285428 is a CYP51 inhibitor. SDZ285428 suppresses Trypanosoma cruzi (TC) CYP51, I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 suppresses Trypanosoma brucei (TB) CYP51, I/E2 <1 (5 min) and I/E2=35 (1 h).
M11137 Dihydromethysticin Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity.
M10656 Bergaptol Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.
M10488 Phthalic acid mono-2-ethylhexyl ester (liquid) Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17.




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