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Cytochrome P450 (e.g. CYP17) Cytochrome P450 (e.g. CYP17)

Inhibitors

Cat.No.  Name Information
M3326 Memantine hydrochloride Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
M11176 Tebuconazole Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively.
M11149 Uniconazole Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols.
M11137 Dihydromethysticin Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity.
M10656 Bergaptol Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.
M9931 ε-​Viniferin ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM.
M9877 Rhapontigenin Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM.
M9684 (Rac)-Brassinazole (Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor.
M8186 Stiripentol Stiripentol (BCX2600) can be used in the study of the third generation of antiepileptic drugs that enhance gaba energy neurotransmission. It's an inhibitor of cytochrome P450.
M6451 Apigenin Apigenin is a protein kinase inhibitor.
M6389 1-Aminobenzotriazole (ABT) 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis.
M5650 Fluconazole Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.
M5059 Furafylline Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM.
M4699 Galangin Galangin (Norizalpinin) is a regulator of arylhydrocarbon receptors and also inhibits the activity of CYP1A1.
M4595 Isosilybin Isosilybin (Isosilybinin) is a flavonoid from milk thistle; The IC50 value induced by CYP3A4 inhibition was 74 μM.
M4573 Diosmetin Diosmetin is a natural flavonoid that inhibits the activity of human CYP1A enzyme. The IC50 value of Diosmetin in HepG2 cells is 40 μM.
M4495 Linderane Linderane was isolated from Lindera Strychnifolia and is an irreversible inhibitor of Cytochrome P450 2C9 (CYP2C9). Linderane has been shown to relieve pain and cramps.
M4414 Gentiopicrin Gentiopicroside is a natural iridoid glycoside that can inhibit the activity of P450 with IC50 and Ki values of 61 µM and 22.8 µM for CYP2A6, respectively. Gentiopicroside has anti-inflammatory and antioxidant activities.
M4376 Forsythin Phillyrin is isolated from forsythia and has antibacterial and anti-inflammatory properties. Phillyrin can potentially induce CYP1A2 and CYP2D1 in rats, but does not affect THE activities of CYP2C11 and CYP3A1/2. Phillyrin has activity against influenza A virus.
M4191 Polygalaxanthone-III Polygalaxanthone III was extracted from Polygala Tenuifolia Wild and had inhibitory effects on CYP450. Polygalaxanthone III inhibited the 6-hydroxylation of clozoxazone catalyzed by CYP2E1 with IC50 of 50.56μM.
M4146 Sodium-Danshensu Danshensu (sodium) is the active component of salvia miltiorrhiza, which can inhibit the formation of reactive oxygen species, inhibit platelet adhesion and aggregation, and protect myocardial ischemia.



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