Catalog

Cytochrome P450 (e.g. CYP17) Cytochrome P450 (e.g. CYP17)

Inhibitors

Cat.No.	Name	Information
M9931	ε-Viniferin	ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM.
M9877	Rhapontigenin	Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM.
M9684	(Rac)-Brassinazole	(Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor.
M8186	Stiripentol	Stiripentol is an LDH inhibitor.
M6451	Apigenin	Apigenin is a protein kinase inhibitor.
M6389	1-Aminobenzotriazole (ABT)	1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis.
M5650	Fluconazole	Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.
M5059	Furafylline	Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM.
M4146	Sodium-Danshensu	Danshensu is an active component of Salvia miltiorrhiza (Danshen) that suppresses the formation of reactive oxygen species, inhibits platelet adhesion and aggregation, and protects myocardium against ischemia.
M4000	Naringenin	Naringenin, a common dietary flavonoid abundantly present in fruits and vegetables, is believed to possess strong anti-proliferative properties and the ability to induce apoptosis in hepatoma cell lines.
M3953	Voriconazole	Voriconazole is an inhibitor of 14α-lanosterol demethylase with IC50 value of 53nM.
M3708	Anastrozole	Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis.
M3591	Abiraterone Acetate	Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM.
M3326	Memantine hydrochloride	Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with K_i of 0.51 nM and 94.9 μM, respectively.
M2537	Cobicistat	Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
M2440	Benzbromarone	Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with K_i value of 19.3 nM.
M2058	Ketoconazole	Ketoconazole is a potent inhibitor of cytochrome P450c17.
M1839	MDV3100	MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity.
M1814	Avasimibe	Avasimibe (CI-1011) is a novel orally bioavailable ACAT inhibitor with IC50 values of 2.9, 13.9, 26.5 µM for CYP2C9, CYP1A2 and CYP2C19, respectively.
M1636	Abiraterone	Abiraterone acetate (CB-7598) is a potent, selective, and orally available inhibitor of CYP17 with an IC50 of 4 nM.

Signaling Pathways

Product Type

Cytochrome P450 (e.g. CYP17) Cytochrome P450 (e.g. CYP17)

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