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(±)-Naringenin blocks the assembly of intracellular infectious viral particles, upstream of viral egress. Naringenin is a non-toxic assembly inhibitor of HCV and that other PPARα agonists play a similar role in blocking viral production. Naringenin is effective at concentrations that are an order of magnitude below the toxic threshold in primary human hepatocytes and in mice.
In vitro Naringenin reduces oxidative damage to DNA. Naringenin potently inhibits the secretion of very-low-density lipoproteins by cells. Naringenin reduces cholesterol concentrations in hepatocytes and plasma cells via inhibiting HMGCR (HMG-CoA reductase). Naringenin seems to protect LDL-receptor deficient mice from the obesity effects of a high-fat diet. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
Phytomedicine. 2024 Sep 27.
Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis
(±)-Naringenin purchased from AbMole
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| Preparation method | |
| Concentrations | |
| Incubation time | |
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| Animal models | Mice |
| Formulation | dispersed in 0.5% sodium carboxymethyl cellulose |
| Dosages | 50 or 100 mg/kg/day |
| Administration | orally gavage |
| Molecular Weight | 272.25 |
| Formula | C15H12O5 |
| CAS Number | 67604-48-2 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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