| Cat.No. | Name | Information |
|---|---|---|
| M3326 | Memantine hydrochloride | Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively. |
| M2079 | Chrysin | Chrysin is a naturally occurring flavone chemically extracted from the passion flowers Passiflora caerulea. |
| M4376 | Forsythin | Phillyrin is isolated from forsythia and has antibacterial and anti-inflammatory properties. Phillyrin can potentially induce CYP1A2 and CYP2D1 in rats, but does not affect THE activities of CYP2C11 and CYP3A1/2. Phillyrin has activity against influenza A virus. |
| M4244 | Schizandrin-A | Schizandrin-A, a lignan from Schisandra chinensis, is also a novel heat shock factor 1 (HSF1) inhibitor that effectively inhibits the induction of HSF1 target proteins such as heat shock protein 70 (HSP70) and HSP27. In addition, Schizandrin-A also regulates lipid metabolism and oxidative stress and possesses neuroprotective activity. |
| M4191 | Polygalaxanthone-III | Polygalaxanthone III was extracted from Polygala Tenuifolia Wild and had inhibitory effects on CYP450. Polygalaxanthone III inhibited the 6-hydroxylation of clozoxazone catalyzed by CYP2E1 with IC50 of 50.56μM. |
| M4146 | Sodium-Danshensu | Danshensu (sodium) is the active component of salvia miltiorrhiza, which can inhibit the formation of reactive oxygen species, inhibit platelet adhesion and aggregation, and protect myocardial ischemia. |
| M4083 | Ginsenoside-F1 | Ginsenoside F1 is an enzymatically modified derivative of Ginsenoside Rg1. Ginsenoside F1 competently inhibits CYP3A4 and has a weak inhibitory effect on CYP2D6. |
| M4000 | (±)-Naringenin | (±)-Naringenin, a common dietary flavonoid abundantly present in fruits and vegetables, is believed to possess strong anti-proliferative properties and the ability to induce apoptosis in hepatoma cell lines. |
| M3953 | Voriconazole | Voriconazole (UK-109496) is an inhibitor of 14α-lanosterol demethylase with IC50 value of 53 nM. Voriconazole (UK-109496) is also a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. |
| M3708 | Anastrozole | Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. |
| M3591 | Abiraterone Acetate | Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM. |
| M3520 | Clobetasol propionate | Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders. |
| M3332 | Alizarin | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| M3235 | Clarithromycin | Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. |
| M3142 | Zoxazolamine | Zoxazolamine is a centrally acting myorelaxant.It is formerly used as an antispasmodic and uricosuric. |
| M2959 | Proadifen hydrochloride | Proadifen hydrochloride is an inhibitor of the cytochrome P450 enzyme that blocks the metabolism of certain types of compounds. |
| M2929 | PF-4981517 | PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. |
| M2537 | Cobicistat | Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| M2515 | Chlorzoxazone | Chlorzoxazone is a muscle-relaxing compound,and a probe for human liver cytochrome P-450IIE1. |
| M2058 | Ketoconazole | Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor. |
| M1833 | Imidaclopride | Imidaclopride is a systemic insecticide which acts as an insect neurotoxin and belongs to a class of chemicals called the neonicotinoids. |
| M1814 | Avasimibe | Avasimibe (CI-1011) is a novel orally bioavailable ACAT inhibitor with IC50 values of 2.9, 13.9, 26.5 µM for CYP2C9, CYP1A2 and CYP2C19, respectively. |
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