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Linderane

Cat. No. M4495
Linderane Structure
Size Price Availability Quantity
20mg USD 200  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Linderane was isolated from Lindera Strychnifolia and is an irreversible inhibitor of Cytochrome P450 2C9 (CYP2C9). Linderane has been shown to relieve pain and cramps.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 260.29
Formula C15H16O4
CAS Number 13476-25-0
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage 4°C , protect from light , dry , sealed
References

[1] Kai Wang, et al. Drug-drug interactions induced by Linderane based on mechanism-based inactivation of CYP2C9 and the molecular mechanisms

[2] Haijun Zhang, et al. Linderane protects pancreatic β cells from streptozotocin (STZ)-induced oxidative damage

[3] Wei Xie, et al. Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3

[4] Saimijiang Yaermaimaiti, et al. Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects

[5] Hui Wang, et al. Mechanism-based inactivation of CYP2C9 by linderane

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Keywords: Linderane supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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