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Isosilybin

Cat. No. M4595
Isosilybin Structure
Synonym:

Isosilybinin

Size Price Availability Quantity
20mg USD 450  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Isosilybin (Isosilybinin) is a flavonoid from milk thistle; The IC50 value induced by CYP3A4 inhibition was 74 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 482.44
Formula C25H22O10
CAS Number 72581-71-6
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Jiazeng Yang, et al. Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis

[2] Jing Zhou, et al. Activation of NRF2/ARE by isosilybin alleviates Aβ25-35-induced oxidative stress injury in HT-22 cells

[3] Gagan Deep, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling

[4] G Deep, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway

[5] Gagan Deep, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells

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Keywords: Isosilybin, Isosilybinin supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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