All AbMole products are for research use only, cannot be used for human consumption.
Abiraterone Acetate (CB 7630) is a highly active and selective 17α-hydroxylase/17,20 lyase (CYP17A1) inhibitor with an IC50 of 72 nM. Abiraterone Acetate (CB 7630) inhibitor CYP11B1, CYP11B2 and CYP3A4 with IC50 of 1.6, 1.8 and 2.7 μM. Abiraterone Acetate (CB 7630) is used in the study of castration-resistant prostate cancer. Abiraterone Acetate (CB 7630) blocks the formation of testosterone by inhibiting CYP17A1. Abiraterone Acetate (CB 7630) caused significant reductions in the weights of the ventral prostate and seminal vesicles. There was no reduction seen in the weight of these organs with KC. Abiraterone Acetate (CB 7630) reduced plasma testosterone to 0.1 nM or less, despite a three- to four-fold increase in the plasma level of luteinizing hormone (LH).
| Cell Experiment | |
|---|---|
| Cell lines | LNCaP and VCaP cells |
| Preparation method | Seeding LNCaP and VCaP cells in 96-well plates and growing in CSS-supplemented phenol red-free or FBS-supplemented media for 7 days.Treatig cells with Abiraterone at 24 hours and 96 hours after plating and determining cell viability on day 7 by adding CellTiter Glo and measuring luminescence |
| Concentrations | 0 μM -10 μM |
| Incubation time | 24 hours and 96 hours |
| Animal Experiment | |
|---|---|
| Animal models | Male NOD/SCID mice with LAPC4 cells |
| Formulation | 0.1 mL 5% benzyl alcohol and 95% safflower oil solution |
| Dosages | 0.5 mmol/kg/d |
| Administration | Administered via s.c. |
| Molecular Weight | 391.55 |
| Formula | C26H33NO2 |
| CAS Number | 154229-18-2 |
| Solubility (25°C) | DMSO 10 mg/mL Ethanol 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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