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Gentiopicrin

Cat. No. M4414
Gentiopicrin Structure
Synonym:

Gentiopicrin

Size Price Availability Quantity
20mg USD 70  USD70 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Gentiopicroside is a natural iridoid glycoside that can inhibit the activity of P450 with IC50 and Ki values of 61 µM and 22.8 µM for CYP2A6, respectively. Gentiopicroside has anti-inflammatory and antioxidant activities.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 356.32
Formula C16H20O9
CAS Number 20831-76-9
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Chen Wu, et al. Effect of swertiamarin, gentiopicrin and sweroside on cell apoptosis and expression of Bcl-2 in rheumatoid arthritis fibroblast-like synoviocytes

[2] Nian Zhang, et al. Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-κB pathway

[3] Lorena Avila-Carrasco, et al. Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition

[4] Kunchi Zhang, et al. Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin

[5] Hong Yin, et al. Gentiopicrin-producing endophytic fungus isolated from Gentiana macrophylla

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Keywords: Gentiopicrin, Gentiopicrin supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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