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Memantine hydrochloride (Memantine HCl) is the hydrochloride salt of Memantine, also a voltage-dependent, non-competitive NMDA receptor antagonist.Memantine binds to and inhibits the cation channel of the NMDA receptor, inhibiting the sustained influx of calcium ions and the associated neuronal excitotoxicity. In addition, Memantine is also an inhibitor of 5-hydroxytryptamine type 3 (5HT3) receptors, nicotinic acetylcholine receptor (nAChR), CYP2B6 and CYP2D6, acting on recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
Discov Med. 2017 Apr;23(127):221-234.
N-methyl-D-aspartate Receptors Mediate Epilepsy-Induced Axonal Impairment and Tau Phosphorylation via Activating Glycogen Synthase Kinase-3β and Cyclin-dependent Kinase 5
Memantine hydrochloride purchased from AbMole
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Source | Discov Med (2017). Figure 5. Memantine (Abmole Bioscience, Houston, TX) |
| Method | Western blot | |
| Cell Lines | Sprague-Dawley rats | |
| Concentrations | 10 mg/kg | |
| Incubation Time | 24 h | |
| Results | PTZ-kindled rats had increased level of Cdk5 in white matters, memantine, ifenprodil, lithium chloride (LiCl), and roscovitine decreased Cdk5 in PTZ-kindled rats. |
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Source | Discov Med (2017). Figure 4. Memantine (Abmole Bioscience, Houston, TX) |
| Method | Immunohistochemistry | |
| Cell Lines | Sprague-Dawley rats | |
| Concentrations | 10 mg/kg | |
| Incubation Time | 24 h | |
| Results | Representative immunohistochemical microphotographs showed increased accumulation of APP in corpus callosum in PTZ-kindled rats. Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated the accumulation. |
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Source | Discov Med (2017). Figure 3. Memantine (Abmole Bioscience, Houston, TX) |
| Method | Immunohistochemistry | |
| Cell Lines | Sprague-Dawley rats | |
| Concentrations | 10 mg/kg | |
| Incubation Time | 24 h | |
| Results | Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated such reduction. |
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Source | Discov Med (2017). Figure 2. Memantine (Abmole Bioscience, Houston, TX) |
| Method | Western blotting | |
| Cell Lines | Sprague-Dawley rats | |
| Concentrations | 10 mg/kg | |
| Incubation Time | 24 h | |
| Results | Memantine, ifenprodil, and LiCl increased tau in PTZ-kindled rats and decreased relative tau phosphorylation level, but failed to decrease p-tau S396 and p-tau T231. |
| Molecular Weight | 215.76 |
| Formula | C12H21N.HCl |
| CAS Number | 41100-52-1 |
| Solubility (25°C) | Water 27 mg/mL DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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