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Memantine hydrochloride

Cat. No. M3326
Memantine hydrochloride Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 40  USD40 In stock
100mg USD 30  USD30 In stock
200mg USD 42  USD42 In stock
500mg USD 60  USD60 In stock
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Quality Control
Biological Activity

Memantine hydrochloride is a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.

Product Citations
Customer Product Validations & Biological Datas
Source Discov Med (2017). Figure 5. Memantine (Abmole Bioscience, Houston, TX)
Method Western blot
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results PTZ-kindled rats had increased level of Cdk5 in white matters, memantine, ifenprodil, lithium chloride (LiCl), and roscovitine decreased Cdk5 in PTZ-kindled rats.
Source Discov Med (2017). Figure 4. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Representative immunohistochemical microphotographs showed increased accumulation of APP in corpus callosum in PTZ-kindled rats. Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated the accumulation.
Source Discov Med (2017). Figure 3. Memantine (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated such reduction.
Source Discov Med (2017). Figure 2. Memantine (Abmole Bioscience, Houston, TX)
Method Western blotting
Cell Lines Sprague-Dawley rats
Concentrations 10 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, and LiCl increased tau in PTZ-kindled rats and decreased relative tau phosphorylation level, but failed to decrease p-tau S396 and p-tau T231.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 215.76
Formula C12H21N.HCl
CAS Number 41100-52-1
Purity >99%
Solubility Water 27 mg/mL
DMSO 30 mg/mL
Storage at -20°C
References

[1] H S Chen, et al. J Physiol. Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

[2] H S Chen, et al. J Neurosci. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

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Keywords: Memantine hydrochloride supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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