Free shipping on all orders over $ 500

Diosmetin

Cat. No. M4573
Diosmetin Structure
Size Price Availability Quantity
20mg USD 50  USD50 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Diosmetin is a natural flavonoid that inhibits the activity of human CYP1A enzyme. The IC50 value of Diosmetin in HepG2 cells is 40 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 300.26
Formula C16H12O6
CAS Number 520-34-3
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Sariya Meephat, et al. Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/HO-1 and p-JNK/p-NF-κB Expression in Hypertensive Rats

[2] Hai-Long Li, et al. Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis

[3] Baocai Xie, et al. Diosmetin Protects Against Obesity and Metabolic Dysfunctions Through Activation of Adipose Estrogen Receptors in Mice

[4] Sariya Meephat, et al. Diosmetin attenuates metabolic syndrome and left ventricular alterations via the suppression of angiotensin II/AT 1 receptor/gp 91 phox/p-NF-κB protein expression in high-fat diet fed rats

[5] Qijun Si, et al. Diosmetin alleviates hypoxia‑induced myocardial apoptosis by inducing autophagy through AMPK activation

Related Cytochrome P450 (e.g. CYP17) Products
Naringin

Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.

Tebuconazole

Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively.

Uniconazole

Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols.

Dihydromethysticin

Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity.

Bergaptol

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Diosmetin supplier, Cytochrome P450 (e.g. CYP17), inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.