Alizarin (Rubia, Rezza, alizarin crimson, crimson madder) is an organic compound and an important prominent dye. Alizarin is the main colorant found in the madder plant Rubia tinctorum. An orange-red crystalline compound used in making red pigments and in dyeing. Alizarin (Rubia, Rezza, alizarin crimson, crimson madder) is produced artificially from anthracene. Alizarin (Rubia, Rezza, alizarin crimson, crimson madder) produces the Turkish reds.
| Molecular Weight | 240.21 |
| Formula | C14H8O4 |
| CAS Number | 72-48-0 |
| Solubility (25°C) | DMSO 38 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Timothy J Mead. Alizarin Red and Alcian Blue Preparations to Visualize the Skeleton
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