About 5 results found for searched term "72-48-0" (0.162 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3332 | Alizarin | Cytochrome P450 (e.g. CYP17) |
| Anthraquinonic | ||
| Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. | ||
| M21640 | Tinlorafenib | Raf |
| PF-07284890; ARRY-461 | ||
| Tinlorafenib (PF-07284890) is an orally active BRAF kinase inhibitor, with IC50 values of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. | ||
| M3484 | Dolutegravir | Integrase |
| GSK1349572 | ||
| Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. | ||
| M3783 | C7280948 | PRMTs |
| C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM. | ||
| M31081 | PF-07284892 | Phosphatase |
| ARRY-558 | ||
| PF-07284892 (ARRY-558) is a potent and orally activity SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases theexpression of pERK. | ||
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