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PF-07284892

Cat. No. M31081

All AbMole products are for research use only, cannot be used for human consumption.

PF-07284892 Structure
Synonym:

ARRY-558

Price and Availability

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Quality Control & Documentation
Biological Activity

PF-07284892 (ARRY-558) is a potent and orally activity SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases theexpression of pERK.

Chemical Information
Molecular Weight 438.98
Formula C22H23ClN6S
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Alexander Drilon, et al. Cancer Discov. SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy

[2] Alberto Hernando-Calvo, et al. Cancer Discov. Patient-Centric Approaches for Phase I Combination Trials Come on Stage

Related Phosphatase Products
RMC-3943 

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM).

LYP-IN-1 

LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively.

PF-07284892

PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC50 value of 21 nM.

MY10 

MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor.

CPDA 

CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: PF-07284892, ARRY-558 supplier, Phosphatase, inhibitors, activators

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