Cat.No. | Name | Information |
---|---|---|
M7533 | SHP099 hydrochloride | SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. |
M6314 | SHP099 | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
M55360 | 4-Methylumbelliferyl phosphate | 4-Methylumbelliferyl phosphate (4-MUP), an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. |
M39164 | (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane | (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane increases the level of alkaline phosphatase (ALP) activity. (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane promotes mesenchymal stem cells (MSCs) osteogenesis, but cannot enhance MSCs proliferation. |
M29659 | SHP2-D26 | SHP2-D26 is a first, potent and effective SHP2 degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. |
M29573 | Migoprotafib | Migoprotafib (GDC-1971) is an orally active allosteric SHP2 inhibitor for studies related to solid tumors. |
M22439 | Enocyanin | Enocyanin |
M21938 | BCI-215 | BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells. |
M21540 | L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) | L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) is a long-term vitamin C derivative that can stimulate the expression and formation of collagen. L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) can be used as a medium to supplement osteogenic differentiation of human adipose stem cells (hASCs). Increased alkaline phosphatase (ALP) activity and runx2A expression in hASC during osteoblast differentiation. |
M20973 | BMOV | BMOV is a potent oral vanadium complex with anti-diabetic properties and insulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models. |
M20873 | Etidronic acid disodium | Etidronate disodium (Etidronate disodium; HEDPA disodium; HEDP disodium) is a nonamino bisphosphonate with protein tyrosine phosphatase (PTP) inhibitory activity. |
M20854 | L-Homoarginine hydrochloride | L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase. |
M20794 | Menadione bisulfite sodium | Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
M20719 | Raphin1 acetate | Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM. |
M20414 | PTP Inhibitor I | PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively. |
M20410 | PTP Inhibitor II | PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM. |
M19381 | Guaiacin | Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation. |
M14489 | DT-061 | DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. |
M14487 | Calyculin A | Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively. |
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