Phosphatase Phosphatase

Inhibitors

Cat.No.	Name	Information
M2849	Microcystin-LR	Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.
M6314	SHP099	SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM.
M7533	SHP099 hydrochloride	SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM.
M14490	BCI hydrochloride	BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP).
M14489	DT-061	DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
M14488	DIPQUO	DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.
M14487	Calyculin A	Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.
M14486	BN82002 hydrochloride	BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family.
M14485	BCI	BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5.
M14484	ARL67156 trisodium salt hydrate	ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase.
M14483	ARL67156 trisodium salt	ARL67156 trisodium salt is an inhibitor of ecto-ATPase.
M14482	Aloe-emodin-8-O-β-D-glucopyranoside	Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
M14481	3α-Aminocholestane	3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM.
M11444	ABBV-CLS-484	Abbv-cls-484 is a potent inhibitor of PTPN1 or PTPN2 with subnanomolar activity.
M11433	PTP1B-IN-1	Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues.
M11432	Razuprotafib	Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM).
M11340	RMC-4630	Rmc-4630 (SHP2-IN-7) is a SHP2 inhibitor derived from patent WO2018013597.
M10582	Rbin-1	Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells).
M10478	Voclosporin (ISATX247)	Voclosporin (ISATX247) is a novel calcineurin (PP2B) (CN) inhibitor.
M10278	Raphin1	Raphin1 is an orally bioavailable, selective R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1) inhibitor, strongly binding to the R15B-PP1c holophosphatase with Kd of 33 nM.
M10027	C2 Ceramide	C2 Ceramide (N-Acetyl-D-sphingosine) is a cell-permeable and biologically active ceramide, it induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.
M9948	SC-43	SC-43 is a sorafenib derivative, it is a potent and orally active SHP-1 (PTPN6) agonist with anti-tumor activity.
M9898	TNO155	TNO155 is a first-in-class, selective, orally active wild-type SHP2 metamorphosis inhibitor with an IC50 value of 0.011 µM. tNO155 has good water solubility (0.736 mM), moderate lipophilicity (LogP=1.6), high lipophilic efficiency (>6), and no hERG inhibition (IC50 >30 μM) and no phototoxicity. Does not inhibit CYP450.

Signaling Pathways

Product Type

Phosphatase Phosphatase

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