| Cat.No. | Name | Information |
|---|---|---|
| M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| M6314 | SHP099 | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
| M7533 | SHP099 hydrochloride | SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. |
| M14487 | Calyculin A | Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively. |
| M14481 | 3α-Aminocholestane | 3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM. |
| M11444 | ABBV-CLS-484 | ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function. |
| M11433 | PTP1B-IN-1 | Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues. |
| M11432 | Razuprotafib | Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM). |
| M11340 | RMC-4630 | Rmc-4630 (SHP2-IN-7) is a SHP2 inhibitor. |
| M11097 | Uralenol | Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor. |
| M10739 | SPI-112 | SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor of SHP2, protein tyrosine phosphatase (PTP) and PTP1B IC50 1 μM, 18.3 μM, and 14.5 μM, respectively. |
| M10738 | IACS-13909 | IACS-13909 is a potent selective, orally active SHP2 allosteric inhibitor IC50 for 15.7 nM,Kd 32 nM. IACS-13909 is more selective for SHP2 than other phosphatase, including SHP1. IACS-13909 inhibits the signaling of the receptor tyrosine kinase (RTK)/MAPK pathway and has an anticancer effect. |
| M10582 | Rbin-1 | Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells). |
| M10478 | Voclosporin (ISATX247) | Voclosporin (VCS, ISATX247) is a novel calcineurin (PP2B) (CN) inhibitor. |
| M10278 | Raphin1 | Raphin1 is an orally bioavailable, selective R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1) inhibitor, strongly binding to the R15B-PP1c holophosphatase with Kd of 33 nM. |
| M10027 | C2 Ceramide | C2 Ceramide (N-Acetyl-D-sphingosine) is a cell-permeable and biologically active ceramide, it induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases. |
| M9948 | SC-43 | SC-43 is a sorafenib derivative, it is a potent and orally active SHP-1 (PTPN6) agonist with anti-tumor activity. |
| M9898 | TNO155 | TNO155 is a first-in-class, selective, orally active wild-type SHP2 metamorphosis inhibitor with an IC50 value of 0.011 µM. tNO155 has good water solubility (0.736 mM), moderate lipophilicity (LogP=1.6), high lipophilic efficiency (>6), and no hERG inhibition (IC50 >30 μM) and no phototoxicity. Does not inhibit CYP450. |
| M9699 | KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 0.25 μM, which protects neurons from cerebral ischemic injury. |
| M9518 | BN82002 | BN82002, also known as CDC25 Phosphatase Inhibitor I, is a potent, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). |
| M9513 | BTdCPU | BTdCPU is an potent activator of HRI, it promotes eIF2α phosphorylation and induced apoptosis in resistant cell. |
| M9467 | F1063-0967 | F1063-0967 is a novel inhibitor of dual-specificity phosphatase 26 (DUSP26), inducing apoptosis in IMR-32 cell line. |
| M9403 | TPI-1 | TPI-1 is a SHP-1 inhibitor, inhibits recombinant SHP-1 with an IC50 of 40 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
