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PTP1B-IN-1

Cat. No. M11433
PTP1B-IN-1 Structure
Synonym:

PTP1B inhibitor

Size Price Availability Quantity
5mg USD 330  USD330 In stock
10mg USD 480  USD480 In stock
25mg USD 800  USD800 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 212.23
Formula C8H8N2O3S
CAS Number 612530-44-6
Purity >98%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: PTP1B-IN-1, PTP1B inhibitor supplier, Phosphatase, inhibitors

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