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About 30 results found for searched term "Phosphatase" (0.013 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1831 | Cyclosporine A | Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. cyclosporin A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| M2865 | Sodium Monofluorophosphate | Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM. |
| M2922 | Pentamidine | Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. |
| M2993 | Sal003 | Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
| M3837 | β-Glycerophosphate disodium salt hydrate | β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. |
| M3943 | Sanguinarine | Sanguinarine, a plant alkaloid with anti-proliferative effects against cancers, is a potent and specific protein phosphatase (PP) 2C inhibitor. |
| M4562 | Cantharidin | Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively). Displays > 500-fold selectivity over PP2B. |
| M4596 | Silydianin | Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro. |
| M21540 | L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) | L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) is a long-term vitamin C derivative that can stimulate the expression and formation of collagen. L-Ascorbic Acid 2-phosphate (magnesium salt hydrate) can be used as a medium to supplement osteogenic differentiation of human adipose stem cells (hASCs). Increased alkaline phosphatase (ALP) activity and runx2A expression in hASC during osteoblast differentiation. |
| M5102 | PTP1B-IN-2 | PTP1B-IN-2 is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. |
| M5161 | Sodium orthovanadate | Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. |
| M5195 | Okadaic acid | Okadaic acid is a potent inhibitor of protein phosphatase 1/2A with IC50 values of 19 nM and 0.2 nM for protein phosphatase 1 and protein phosphatase 2A, respectively. |
| M8990 | LB-100 | LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
| M5348 | (-)-Tetramisole | (-)-Tetramisole is an inhibitor of alkaline phosphatase, used as an anthelmintic. |
| M5632 | Etidronate | Etidronate is a class of non-aminobisphosphate that inhibits human protein tyrosine phosphatase activity and is used in the study of Paget's disease and in the prevention of ectopic ossification. |
| M5767 | Menadione（Vitamin K3） | Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
| M5869 | Pentamidine isethionate | Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. |
| M5986 | Suramin sodium salt | Suramin Sodium Salt (Suramin hexasodium salt) is a reversible inhibitor of competitive protein tyrosine phosphatases (PTPases). |
| M6293 | Tacrolimus monohydrate | Tacrolimus monohydrate binds to FK506 binding protein (FKBP). This complex inhibits calcineurin phosphatase (PP2B). Tacrolimus monohydrate is a mTOR-independent autophagy inducer. |
| M6300 | (-)-p-Bromotetramisole Oxalate | (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor. |
| M6383 | A12B4C3 | A12B4C3 is a potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor. |
| M6542 | BVT 948 | BVT 948 is a non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling. |
| M6727 | PFK-158 | PFK-158, also known as ACT-PFK-158, is a potent and selective inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) with potential antineoplastic activity. |
| M6770 | GSK 2830371 | GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase. |
| M6881 | L-690,330 | L-690,330 is a inositol monophosphatase inhibitor. |
| M7057 | NSC 663284 | NSC 663284 is a potent, selective Cdc25 phosphatase inhibitor. |
| M7059 | NSC 87877 | Nsc-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatase with IC50 values of 0.318 μM and 0.355 μM, respectively. Nsc-87877 also inhibits bispecific phosphatase 26 (DUSP26). |
| M7060 | NSC 95397 | NSC 95397 is a selective Cdc25 dual specificity phosphatase inhibitor. |
| M7246 | Sanguinarine chloride | Sanguinarine chloride is a inhibitor of protein phosphatase 2C (PP2C). |
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