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BN82002

Cat. No. M9518
BN82002 Structure
Synonym:

CDC25 Phosphatase Inhibitor I

Size Price Availability Quantity
5mg USD 105  USD105 In stock
10mg USD 145  USD145 In stock
50mg USD 440  USD440 In stock
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Quality Control & Documentation
Biological Activity

BN82002 is a cell-permeable ortho-hydroxybenzylamino compound that displays anti-tumor properties. BN82002 inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro. It impairs the proliferation of tumoral cell lines and increases cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation. BN82002 delays cell cycle progression at G1-S, in S phase and at the G2-M transition in synchronized HeLa cells.

Chemical Information
Molecular Weight 359.42
Formula C19H25N3O4
CAS Number 396073-89-5
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Brenner AK, et al. Molecules. CDC25 Inhibition in Acute Myeloid Leukemia-A Study of Patient Heterogeneity and the Effects of Different Inhibitors.

[2] Brezak MC, et al. Cancer Res. A novel synthetic inhibitor of CDC25 phosphatases: BN82002.

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  Catalog
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Keywords: BN82002, CDC25 Phosphatase Inhibitor I supplier, Phosphatase, inhibitors, activators


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