Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.
Comp Biochem Physiol C Toxicol Pharmacol. 2018 Aug;210:18-29.
Structural and functional analysis of two novel somatostatin receptors identified from topmouth culter (Erythroculter ilishaeformis)
Microcystin-LR purchased from AbMole
|Source||Comp Biochem Physiol C Toxicol Pharmacol (2018). Figure 6. MC-LR (AbMole BioScience,Shanghai, China)|
|Concentrations||2 μg/L, 20 μg/L|
|Incubation Time||30 days|
|Results||In the brain, the transcription of the two receptors was increased after MC-LR treatment, whereas in the liver and spleen, it was markedly upregulated at low MC-LR concentration (2 μg/L) and downregulated at high MC-LR concentration (20 μg/L) compared with the control group|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Ethanol ≥ 0.5 mg/mL|
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