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Microcystin-LR

Cat. No. M2849
Microcystin-LR Structure
Synonym:

Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa)

Size Price Availability Quantity
50ug USD 180  USD180 In stock
100ug USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.

Product Citations
Customer Product Validations & Biological Datas
Source Comp Biochem Physiol C Toxicol Pharmacol (2018). Figure 6. MC-LR (AbMole BioScience,Shanghai, China)
Method qRT-PCR
Cell Lines fish
Concentrations 2 μg/L, 20 μg/L
Incubation Time 30 days
Results In the brain, the transcription of the two receptors was increased after MC-LR treatment, whereas in the liver and spleen, it was markedly upregulated at low MC-LR concentration (2 μg/L) and downregulated at high MC-LR concentration (20 μg/L) compared with the control group
Chemical Information
Molecular Weight 995.17
Formula C49H74N10O12
CAS Number 101043-37-2
Solubility (25°C) Ethanol ≥ 0.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yaqoob Lone, et al. J Toxicol. Microcystin-LR Induced Immunotoxicity in Mammals

[2] R E Honkanen, et al. J Biol Chem. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases

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Keywords: Microcystin-LR, Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa) supplier, Phosphatase, inhibitors, activators


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