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Microcystin-LR

Cat. No. M2849
Microcystin-LR Structure
Synonym:

Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa)

Size Price Availability Quantity
50μg USD 180  USD180 In stock
100μg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.

Product Citations
Customer Product Validations & Biological Datas
Source Comp Biochem Physiol C Toxicol Pharmacol (2018). Figure 6. MC-LR (AbMole BioScience,Shanghai, China)
Method qRT-PCR
Cell Lines fish
Concentrations 2 μg/L, 20 μg/L
Incubation Time 30 days
Results In the brain, the transcription of the two receptors was increased after MC-LR treatment, whereas in the liver and spleen, it was markedly upregulated at low MC-LR concentration (2 μg/L) and downregulated at high MC-LR concentration (20 μg/L) compared with the control group
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 995.17
Formula C49H74N10O12
CAS Number 101043-37-2
Purity >95%
Solubility Ethanol ≥ 0.5 mg/mL
Storage at -20°C
References

[1] Yaqoob Lone, et al. J Toxicol. Microcystin-LR Induced Immunotoxicity in Mammals

[2] R E Honkanen, et al. J Biol Chem. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases

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Keywords: Microcystin-LR, Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa) supplier, Phosphatase, inhibitors

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