Free shipping on all orders over $ 500
Razuprotafib (AKB-9778) is an effective selective inhibitor of ve-PTP (HPTPß) catalytic activity (IC50=17 pM), which promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signal molecules in TIE2 pathway. Including AKT, eNOS, and ERK. Razuprotafib inhibited structure-related phosphatase PTP1B with an IC50 of 780 nM. Besides HPTPη (IC50=36 pM) and HPTPγ (100 pM), Razuprotafib showed good selectivity to VE-PTP.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 586.70 |
| Formula | C26H26N4O6S3 |
| CAS Number | 1008510-37-9 |
| Purity | >99% |
| Solubility | DMSO ≥ 60 mg/mL |
| Storage | at -20°C |
| Related Phosphatase Products |
|---|
| Trodusquemine
MSI-1436 is a non-competitive inhibitor of PTP1B with a selective IC50 of 1 μM and an IC50 value of 224 μM for TCPTP. |
| Etidronic acid disodium
Etidronate disodium (Etidronate disodium; HEDPA disodium; HEDP disodium) is a nonamino bisphosphonate with protein tyrosine phosphatase (PTP) inhibitory activity. |
| L-Homoarginine hydrochloride
L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase. |
| PHPS1
PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM. |
| Menadione bisulfite sodium
Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
