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CCT007093

Cat. No. M2499
CCT007093 Structure
Size Price Availability Quantity
5mg USD 45  USD45 In stock
10mg USD 75  USD75 In stock
50mg USD 270  USD270 In stock
100mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.

Chemical Information
Molecular Weight 272.39
Formula C15H12OS2
CAS Number 176957-55-4
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qianxue Mou, et al. Modulation of Sirt1-mTORC1 Pathway in Microglia Attenuates Retinal Ganglion Cell Loss After Optic Nerve Injury

[2] Ji-Seon Lee, et al. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes

[3] Meghan C Buss, et al. HDM2 promotes WIP1-mediated medulloblastoma growth

[4] Joshua A Bauer, et al. RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells

[5] David S P Tan, et al. PPM1D is a potential therapeutic target in ovarian clear cell carcinomas

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