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 About 17 results found for searched term "PTP1B-IN-1" (0.125 seconds)

Cat.No.  Name Target
M11433 PTP1B-IN-1 Phosphatase
PTP1B inhibitor
Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues.
M42536 PTP1B/AKR1B1-IN-1 Phosphatase
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM and 4.3 μM, respectively.
M56740 PTP1B-IN-15  Phosphatase
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
M4324 Rhein-8-O-β-D-glucopyranoside Phosphatase
Rhein-8-glucoside calcium, a anthraquinone compound isolated from EtOH extract of Saussurea lappa root. Rhein-8-glucoside calcium is an hPTP1B inhibitor with an IC50 value of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects.
M4596 Silydianin Phosphatase
Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro.
M5102 PTP1B-IN-2 Phosphatase
PTP1B-IN-2 is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM.
M11097 Uralenol Phosphatase
Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor.
M18517 Ishophloroglucin A Others
IPA
Ishophloroglucin A, isolated from Ishige okamurae, is a potent PTP1B inhibitor with IC50 of 0.43 μM, inhibits adipogenesis in 3T3-L1 adipocytes.
M28513 DPM-1001  Phosphatase
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property.
M29684 Ertiprotafib Phosphatase
PTP 112
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
M30078 bpV(phen)  PTEN
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity.
M30586 PTP1B-IN-4  Phosphatase
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes.
M30782 JUN-1111  Phosphatase
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1.
M31059 DPM-1001 trihydrochloride  Phosphatase
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property.
M42549 PTP1B/AKR1B1-IN-2 Phosphatase
PTP1B/AKR1B1-IN-2 is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM).
M56743 PTP1B-IN-3  Phosphatase
PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP.
M56734 PTP1B-IN-3 diammonium  Phosphatase
PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP.



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