About 14 results found for searched term "PTP1B-IN-1" (0.701 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M11433 | PTP1B-IN-1 | Phosphatase |
| PTP1B inhibitor | ||
| Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues. | ||
| M42536 | PTP1B/AKR1B1-IN-1 | Phosphatase |
| PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM and 4.3 μM, respectively. | ||
| M4324 | Rhein-8-O-β-D-glucopyranoside | Phosphatase |
| Rhein-8-glucoside calcium, a anthraquinone compound isolated from EtOH extract of Saussurea lappa root. Rhein-8-glucoside calcium is an hPTP1B inhibitor with an IC50 value of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects. | ||
| M4596 | Silydianin | Phosphatase |
| Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro. | ||
| M5102 | PTP1B-IN-2 | Phosphatase |
| PTP1B-IN-2 is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. | ||
| M11097 | Uralenol | Phosphatase |
| Uralenol is a natural PTP1B inhibitor (IC50=21. 5 μM) from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor. | ||
| M18517 | Ishophloroglucin A | Others |
| IPA | ||
| Ishophloroglucin A, isolated from Ishige okamurae, is a potent PTP1B inhibitor with IC50 of 0.43 μM, inhibits adipogenesis in 3T3-L1 adipocytes. | ||
| M28513 | DPM-1001 | Phosphatase |
| DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property. | ||
| M29684 | Ertiprotafib | Phosphatase |
| PTP 112 | ||
| Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. | ||
| M30078 | bpV(phen) | PTEN |
| bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity. | ||
| M30586 | PTP1B-IN-4 | Phosphatase |
| PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes. | ||
| M30782 | JUN-1111 | Phosphatase |
| JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1. | ||
| M31059 | DPM-1001 trihydrochloride | Phosphatase |
| DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property. | ||
| M42549 | PTP1B/AKR1B1-IN-2 | Phosphatase |
| PTP1B/AKR1B1-IN-2 is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM). | ||
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