C2 Ceramide (N-Acetyl-D-sphingosine) is a cell-permeable and biologically active ceramide, it induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases. C2 Ceramide (N-Acetyl-D-sphingosine) produces concentration-dependent impairment of vasorelaxation in response to the endothelium-dependent agonist acetylcholine in nontransgenic mice.
| Molecular Weight | 341.53 |
| Formula | C20H39NO3 |
| CAS Number | 3102-57-6 |
| Solubility (25°C) | Soluble in DMSO Soluble in ethanol |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] P A Hill, et al. J Endocrinol. Ceramide-induced cell death/survival in murine osteoblasts
[2] R T Dobrowsky, et al. J Biol Chem. Ceramide activates heterotrimeric protein phosphatase 2A
[3] R T Dobrowsky, et al. J Biol Chem. Ceramide stimulates a cytosolic protein phosphatase
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