Free shipping on all orders over $ 500

ABBV-CLS-484

Cat. No. M11444
ABBV-CLS-484  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Abbv-cls-484 is a potent inhibitor of PTPN1 or PTPN2 with subnanomolar activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 385.45
Formula C17H24FN3O4S
CAS Number 2489404-97-7
Purity
Solubility N/A
Storage at -20°C
Related Phosphatase Products
PTP1B-IN-1

Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues.

Razuprotafib

Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM).

RMC-4630

Rmc-4630 (SHP2-IN-7) is a SHP2 inhibitor derived from patent WO2018013597.

Rbin-1

Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells).

Voclosporin (ISATX247)

Voclosporin (ISATX247) is a novel calcineurin (PP2B) (CN) inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: ABBV-CLS-484 supplier, Phosphatase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.