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ABBV-CLS-484

Cat. No. M11444
ABBV-CLS-484  Structure
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Biological Activity

Abbv-cls-484 is a potent inhibitor of PTPN1 or PTPN2 with subnanomolar activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 385.45
Formula C17H24FN3O4S
CAS Number 2489404-97-7
Purity
Solubility N/A
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: ABBV-CLS-484 supplier, Phosphatase, inhibitors

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