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ABBV-CLS-484

Cat. No. M11444

All AbMole products are for research use only, cannot be used for human consumption.

ABBV-CLS-484  Structure
Synonym:

Osunprotafib; AC484

Size Price Availability Quantity
1mg USD 510  USD510 In stock
5mg USD 1400  USD1400 In stock
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Quality Control & Documentation
Biological Activity

ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function.

Chemical Information
Molecular Weight 385.45
Formula C17H24FN3O4S
CAS Number 2489404-97-7
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christina K Baumgartner, et al. Nature. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

[2] Shuwei Liang, et al. Nat Commun. A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

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  Catalog
Abmole Inhibitor Catalog




Keywords: ABBV-CLS-484 , Osunprotafib; AC484 supplier, Phosphatase, inhibitors, activators

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