Free shipping on all orders over $ 500

Calyculin A

Cat. No. M14487
Calyculin A Structure
Synonym:

(-)-Calyculin A

Size Price Availability
10ug USD 120  USD120 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1009.17
Formula
CAS Number 101932-71-2
Purity >99%
Solubility
Storage at -20°C
References

[1] Honami Ogata, et al. Effects of Calyculin a on the Motility and Protein Phosphorylation in Frozen-Thawed Bull Spermatozoa

[2] Lucin Zastko, et al. Evaluation of Calyculin A Effect on γH2AX/53BP1 Focus Formation and Apoptosis in Human Umbilical Cord Blood Lymphocytes

[3] Mingzhu Sun, et al. A faster and easier biodosimetry method based on calyculin A-induced premature chromosome condensation (PCC) by scoring excess objects

[4] Jinfeng Zhao, et al. Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD

[5] Mingzhu Sun, et al. A Simplified Calyculin A-Induced Premature Chromosome Condensation (PCC) Protocol for the Biodosimetric Analysis of High-Dose Exposure to Gamma Radiation

Related Phosphatase Products
Etidronic acid disodium

Etidronate disodium (Etidronate disodium; HEDPA disodium; HEDP disodium) is a nonamino bisphosphonate with protein tyrosine phosphatase (PTP) inhibitory activity.

L-Homoarginine hydrochloride

L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.

PHPS1

PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.

Menadione bisulfite sodium

Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

(E/Z)-BCI

(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: Calyculin A, (-)-Calyculin A supplier, Phosphatase, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.