| Cat.No. | Name | Information |
|---|---|---|
| M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| M6314 | SHP099 | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
| M7533 | SHP099 hydrochloride | SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. |
| M14493 | MSI-1436 lactate | MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM). |
| M3837 | β-Glycerophosphate disodium salt hydrate | β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. |
| M39167 | Uralsaponin D | Uralsaponin D is a saponin that can be isolated from Glycyrrhiza inflata. Uralsaponin D inhibits phospholipase A2 (PLA2) with an IC50 value of 32.2 μM. |
| M39166 | Momordicoside A | Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on protein tyrosine phosphatase (PTP1B). |
| M39165 | 2-Hydroxymethyl-3-hydroxyanthraquinone | 2-Hydroxymethyl-3-hydroxyanthraquinone is an antiosteoporotic compound that inhibits osteoclastic tartrate-resistant acid phosphatase (TRAP) activity. |
| M39163 | 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) | 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. |
| M31081 | PF-07284892 | PF-07284892 (ARRY-558) is a potent and orally activity SHP2 inhibitor with an IC50 value of 21 nM. PF-07284892 decreases theexpression of pERK. |
| M31059 | DPM-1001 trihydrochloride | DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property. |
| M30782 | JUN-1111 | JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1. |
| M30606 | Rosiptor acetate | Rosiptor (AQX-1125) acetate is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor acetate (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro. |
| M30586 | PTP1B-IN-4 | PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes. |
| M30315 | PRL-3 Inhibitor 2 | PRL-3 Inhibitor 2 (compound 2) is a potent PRL-3 inhibitor with an IC50 value of 28.1 µM. |
| M29736 | SHP2 protein degrader-1 | SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases. |
| M29684 | Ertiprotafib | Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. |
| M29499 | LMPTP inhibitor 1 dihydrochloride | LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
| M29498 | LMPTP inhibitor 1 hydrochloride | LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
| M29486 | SHP2 inhibitor LY6 | SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of SHP2, with an IC50 of 9.8 µM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation. |
| M29321 | SHP2-IN-6 hydrochloride | SHP2-IN-6 hydrochloride is a potent SHP2 inhibitor that interferes with the MAPK signaling pathway and inhibits the proliferation of SHP2-expressing tumor cells with an IC50 value of 25.8 nM. |
| M29320 | SHP2-IN-6 | SHP2-IN-6 is a potent SHP2 inhibitor that interferes with the MAPK signaling pathway and inhibits the proliferation of SHP2-expressing tumor cells with an IC50 value of 25.8 nM. |
| M29216 | Isotanshinone IIA | Isotanshinone IIA, an abietane-type diterpene metabolite, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. |
| M29196 | Okadaic acid sodium | Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. |
| M29013 | LMPTP inhibitor 1 | LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
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