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MSI-1436 lactate

Cat. No. M14493
MSI-1436 lactate Structure
Synonym:

Trodusquemine lactate; Aminosterol-1436 lactate

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1000.17
Formula
CAS Number 1309370-86-2
Purity >99%
Solubility DMSO 54 mg/mL
Water ≥ 33.33 mg/mL
Storage 2-8°C, dry, sealed
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Keywords: MSI-1436 lactate, Trodusquemine lactate; Aminosterol-1436 lactate supplier, Phosphatase, inhibitors

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