Free shipping on all orders over $ 500

Etidronic acid disodium

Cat. No. M20873
Etidronic acid disodium Structure

Etidronate disodium; HEDPA disodium; HEDP disodium

Size Price Availability Quantity
500mg USD 48  USD48 In stock
1g USD 75  USD75 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity.

Chemical Information
Molecular Weight 249.99
Formula C2H6Na2O7P2
CAS Number 7414-83-7
Solubility (25°C) Water 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] No authors listed. Prescrire Int. Etidronic acid and steroid therapy: new indication. No proven impact on fractures

[2] C Crandall. Arch Intern Med. Risedronate: a clinical review

[3] M Stone. Br J Hosp Med. Didronel PMO

[4] D J Hosking. Drugs. Advances in the management of Paget's disease of bone

[5] K S Eyres, et al. Drug Saf. Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate)

Related Phosphatase Products

5MPN is a first-in-class, orally active and selective inhibitor of fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4), which does not inhibit PFK-1 or PFKFB3. 5MPN is a competitive inhibitor of the F6P-binding site (Ki=8.6 μM). 5MPN inhibits proliferation of various cancer cell lines by targeting tumor glucose metabolism. 5MPN is a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN can inhibit the proliferation of various cancer cell lines by targeting tumor glycolysis.

Tartaric acid disodium dihydrate

Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications. Tartaric acid disodium dihydrate increases the rate of colchicine binding to tubulin1.


YF704 is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM).


CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM.


SHP2-IN-14 is an orally active and potent SHP2 allosteric inhibitor (IC50=7 nM) with anti-tumor activity.

Abmole Inhibitor Catalog

Keywords: Etidronic acid disodium, Etidronate disodium; HEDPA disodium; HEDP disodium supplier, Phosphatase, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.