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Etidronic acid disodium

Cat. No. M20873
Etidronic acid disodium Structure
Synonym:

Etidronate disodium; HEDPA disodium; HEDP disodium

Size Price Availability Quantity
500mg USD 48  USD48 In stock
1g USD 75  USD75 In stock
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Quality Control & Documentation
Biological Activity

Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity.

Chemical Information
Molecular Weight 249.99
Formula C2H6Na2O7P2
CAS Number 7414-83-7
Solubility (25°C) Water 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Prescrire Int. Etidronic acid and steroid therapy: new indication. No proven impact on fractures

[2] C Crandall. Arch Intern Med. Risedronate: a clinical review

[3] M Stone. Br J Hosp Med. Didronel PMO

[4] D J Hosking. Drugs. Advances in the management of Paget's disease of bone

[5] K S Eyres, et al. Drug Saf. Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate)

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Keywords: Etidronic acid disodium, Etidronate disodium; HEDPA disodium; HEDP disodium supplier, Phosphatase, inhibitors, activators


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