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L-Homoarginine hydrochloride

Cat. No. M20854
L-Homoarginine hydrochloride Structure
Size Price Availability Quantity
100mg USD 60  USD60 In stock
250mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.

Chemical Information
Molecular Weight 224.69
Formula C7H17ClN4O2
CAS Number 1483-01-8
Solubility (25°C) Water 44 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Duygu Naile Gnes, et al. Amino Acids. Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat

[2] Ming-Tao Gao, et al. Biotechnol Prog. Interactions between L-arginine/L-arginine derivatives and lysozyme and implications to their inhibition effects on protein aggregation

[3] P J Andrew, et al. Biochem Biophys Res Commun. Nitric oxide regulates IL-8 expression in melanoma cells at the transcriptional level

[4] O A al-Swayeh, et al. J Pharm Pharmacol. Amino acids dilate resistance blood vessels of the perfused rat mesentery

[5] M Suwalsky, et al. Biopolymers. An X-ray diffraction study of poly-L-homoarginine hydrochloride

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Keywords: L-Homoarginine hydrochloride supplier, Phosphatase, inhibitors, activators

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