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Menadione bisulfite sodium

Cat. No. M20794
Menadione bisulfite sodium Structure
Synonym:

Menadione sodium bisulfite, Vitamin K3 sodium bisulfite

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 276.24
Formula C11H9NaO5S
CAS Number 130-37-0
Purity >99%
Solubility DMSO 55 mg/mL
Water 55 mg/mL
Storage at -20°C
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Keywords: Menadione bisulfite sodium, Menadione sodium bisulfite, Vitamin K3 sodium bisulfite supplier, Phosphatase, inhibitors

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