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JMS-053 

Cat. No. M29054

All AbMole products are for research use only, cannot be used for human consumption.

JMS-053  Structure

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Quality Control & Documentation
Biological Activity

JMS-053 is a potent, selective and reversible PTP4A inhibitor, with IC50s of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM, and 207.6 nM for PTP4A1, PTP4A2, PTP4A3, CDC25B, and DUSP3, respectively. JMS-053 can inhibit cancer cell migration and spheroid growth in vitro, attenuate in vivo ovarian tumor growth.

Chemical Information
Molecular Weight 256.28
Formula C13H8N2O2S
CAS Number 1954650-11-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] John S Lazo, et al. Biomolecules. Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer

[2] Ettore J Rastelli, et al. Bioorg Med Chem Lett. Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway

[3] John S Lazo, et al. J Pharmacol Exp Ther. Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

[4] Kelley E McQueeney, et al. FASEB J. A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion

[5] John S Lazo, et al. J Pharmacol Exp Ther. Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase

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  Catalog
Abmole Inhibitor Catalog




Keywords: JMS-053  supplier, Phosphatase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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