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Pregnenolone 16α-carbonitrile is a derivative of pregnendione that functions as an agonist of the rodent pregnane X receptor (PXR). pregnenolone 16α-carbonitrile is a synthetic steroid that induces expression of cytochrome P450 3A. Pregnenolone 16α-carbonitrile exhibits greater tolerance to subsequent stress injury.
Molecular Weight | 341.49 |
Formula | C22H31NO2 |
CAS Number | 1434-54-4 |
Solubility (25°C) | DMSO : 33.33 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Related Cytochrome P450 (e.g. CYP17) Products |
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(S)-Mephenytoin
(S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism. |
Cytochrome P450 reductase
Cytochrome P450 reductase is a NADPH-cytochrome reductase. |
20-SOLA
20-SOLA is a water-soluble 20-HETE antagonist. |
TS-011
TS-011 is a selective inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis. |
Dibromo-dodecenyl-methylsulfimide
Dibromo-dodecenyl-methylsulfimide is a selective inhibitor of 20-HETE synthesis and attenuates the vasodilatory response to sodium nitroprusside (SNP). |
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