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Pregnenolone 16α-carbonitrile

Cat. No. M21085

All AbMole products are for research use only, cannot be used for human consumption.

Pregnenolone 16α-carbonitrile Structure
Synonym:

PCN

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5mg USD 60 In stock
10mg USD 100 In stock
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Biological Activity

Pregnenolone 16α-carbonitrile is a derivative of pregnendione that functions as an agonist of the rodent pregnane X receptor (PXR). pregnenolone 16α-carbonitrile is a synthetic steroid that induces expression of cytochrome P450 3A. Pregnenolone 16α-carbonitrile exhibits greater tolerance to subsequent stress injury.

Chemical Information
Molecular Weight 341.49
Formula C22H31NO2
CAS Number 1434-54-4
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Peihua Liu, et al. Acta Pharm Sin B. PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4 α-GLUT2 pathway

[2] Zhilin Luan, et al. Biochim Biophys Acta Mol Basis Dis. Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice

[3] Chuanzhu Lv, et al. Acta Pharm Sin B. Xenobiotic receptors in mediating the effect of sepsis on drug metabolism

[4] Yuki Yamasaki, et al. Biol Pharm Bull. Effect of Pregnenolone 16α-Carbonitrile on the Expression of P-Glycoprotein in the Intestine, Brain and Liver of Mice

[5] Susumu Kodama, et al. Toxicol Lett. Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation

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Keywords: Pregnenolone 16α-carbonitrile , PCN supplier, Pregnane X Receptor, inhibitors, activators

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