Free shipping on all orders over $ 500


Cat. No. M21437

All AbMole products are for research use only, cannot be used for human consumption.

HET0016  Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

HET0016 is a highly efficient and selective inhibitor of 20-HETE synthase, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1, CYP4A2 and CYP4A3, respectively. HET0016 is a selective CYP450 inhibitor that has been shown to inhibit angiogenesis and tumor growth.

Chemical Information
Molecular Weight 206.28
Formula C12H18N2O
CAS Number 339068-25-6
Solubility (25°C) DMSO : 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] Jie Wu, et al. Cell Death Dis. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages

[2] Hai Liu, et al. Mol Carcinog. HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1

[3] Thaiz F Borin, et al. PLoS One. HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

[4] Thaiz Ferraz Borin, et al. PLoS One. HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice

[5] N Miyata, et al. Br J Pharmacol. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

Related Cytochrome P450 (e.g. CYP17) Products

(S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism.

Cytochrome P450 reductase

Cytochrome P450 reductase is a NADPH-cytochrome reductase.


20-SOLA is a water-soluble 20-HETE antagonist.


TS-011 is a selective inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis.


Dibromo-dodecenyl-methylsulfimide is a selective inhibitor of 20-HETE synthesis and attenuates the vasodilatory response to sodium nitroprusside (SNP).

Abmole Inhibitor Catalog

Keywords: HET0016 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.