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HET0016

Cat. No. M21437

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HET0016  Structure
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Biological Activity

HET0016 is a highly efficient and selective inhibitor of 20-HETE synthase, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1, CYP4A2 and CYP4A3, respectively. HET0016 is a selective CYP450 inhibitor that has been shown to inhibit angiogenesis and tumor growth.

Chemical Information
Molecular Weight 206.28
Formula C12H18N2O
CAS Number 339068-25-6
Solubility (25°C) DMSO : 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jie Wu, et al. Cell Death Dis. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages

[2] Hai Liu, et al. Mol Carcinog. HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1

[3] Thaiz F Borin, et al. PLoS One. HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

[4] Thaiz Ferraz Borin, et al. PLoS One. HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice

[5] N Miyata, et al. Br J Pharmacol. HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme

Related Cytochrome P450 (e.g. CYP17) Products
(S)-Mephenytoin

(S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism.

Cytochrome P450 reductase

Cytochrome P450 reductase is a NADPH-cytochrome reductase.

20-SOLA

20-SOLA is a water-soluble 20-HETE antagonist.

TS-011

TS-011 is a selective inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis.

Dibromo-dodecenyl-methylsulfimide

Dibromo-dodecenyl-methylsulfimide is a selective inhibitor of 20-HETE synthesis and attenuates the vasodilatory response to sodium nitroprusside (SNP).

  Catalog
Abmole Inhibitor Catalog




Keywords: HET0016 supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators

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