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Sophoraflavanone G

Cat. No. M16672
Sophoraflavanone G Structure
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Biological Activity

Sophoraflavanone G

Chemical Information
CAS Number 97938-30-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chung-Pu Wu, et al. J Nat Prod. Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs

[2] Zhong-Lin Sun, et al. Int J Antimicrob Agents. Synergism of sophoraflavanone G with norfloxacin against effluxing antibiotic-resistant Staphylococcus aureus

[3] Wen-Chung Huang, et al. Phytomedicine. Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells

[4] Zhixin Yang, et al. J Sep Sci. Determination of sophoraflavanone G and kurarinone in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study

[5] Byung-Hak Kim, et al. Biochem Pharmacol. Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs

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