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VE-822

Cat. No. M3115
VE-822 Structure
Size Price Availability Quantity
10mg USD 110 In stock
50mg USD 350 In stock
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Quality Control
Biological Activity

VE-822 is an ATR inhibitor with IC50 of 19 nM.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models mice bearing PSN-1 or MiaPaCa-2 tumors
Formulation saline
Dosages 60 mg/kg
Administration Oral gavage
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 463.55
Formula C24H25N5O3S
CAS Number 1232416-25-9
Purity 100.00%
Solubility DMSO 20 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Cancer Res (2017). VE-822, Figure 7. (AbMole BioScience)
Method
Cell Lines KP-, KPAfl/Δ- and KPAΔ/Δ cells
Concentrations 0.1μM
Incubation Time
Results As shown in Figure 7A-C, VE-822 treatment (30mg/kg, orally, days 1-3, 8-10, 15-17) of KP- and KPAfl/Δ-tumor bearing mice did not result in any significant tumor volume changes, compared to vehicle-treated controls.
Rating
Source Cancer Res (2017). VE-822, Figure 5. (AbMole BioScience)
Method
Cell Lines KP-, KPAfl/Δ- and KPAΔ/Δ cells
Concentrations 0.1μM
Incubation Time 72 h
Results VE-822 exposure led to a substantial and significant reduction in surviving KPAΔ/Δ colonies, compared to vehicle controls (p < 0.0001) (Fig. 5E, F). Of note, the cytotoxic effect of VE-822 was significantly more pronounced in KPAΔ/Δ cells, compared to KP- and KPAfl/Δcells (p < 0.0001 and p < 0.0001, respectively) (Fig. 5D). VE-822 was genotoxic in all three genotypes and induced maximal damage at 24 hours following drug exposure (Fig. 5I, J, S8B).
Rating
Product Citations
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VE-822 supplier, ATM/ATR, inhibitors

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