Free shipping on all orders over $ 500

Rosiglitazone

Cat. No. M1894

Rosiglitazone Structure

Synonym: BRL 49653

Size Price Availability Quantity
100mg USD 110 In stock
200mg USD 180 In stock
500mg USD 300 In stock
Bulk Inquiry?

Quality Control
Biological Activity

Rosiglitazone, also known as BRL 49653, is a potent and selective agonist for PPARγ (Peroxisome proliferator-activated receptor) with an EC50 of 43 nM. PPARγ plays a functional role in adipogenesis, it belongs to a group of nuclear receptor proteins that are essential to the regulation of cellular differentiation, development and metabolism. Rosiglitazone binds to the PPAR receptors in fat cells and making the cells more responsive to insulin. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone induced adipocyte differentiation in pluripotent C3H10T1/2 stem cells. Rosiglitazone suppressed the activity of complex I of the MRC in ob/ob mice, but did not affect beta-oxidation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 357.43
Formula C18H19N3O3S
CAS Number 122320-73-4
Purity >99%
Solubility DMSO 25 mg/mL
Storage at -20°C
References

Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice.
García-Ruiz I, et al. Hepatology. 2007 Aug;46(2):414-23. PMID: 17654601.

Related PPAR Products
Rosiglitazone HCl

Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Retinoic acid

All-trans retinoic acid (ATRA; Vitamin A acid) has been widely investigated for treatments of many cancers including prostate cancer.

Pioglitazone HCl

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

Fenofibric acid

Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

Clofibrate

Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Rosiglitazone, BRL 49653 supplier, PPAR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.