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PPAR Peroxisome Proliferator Activated Receptor

Inhibitors

Cat.No.  Name Information
M5940 Rosiglitazone HCl Rosiglitazone HCl is a hypoglycemic compound that stimulates insulin secretion by binding to PPAR receptors in fat cells.
M2748 GW9662 GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.
M1880 WY 14643 (Pirinixic Acid) WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist.
M2335 ZLN005 ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator.
M5878 Pioglitazone HCl Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.
M21446 AZD-9574 AZD-9574 is a potent blood-brain barrier permeability inhibitor of PARP1, showing > 8,000 times selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 selectively inhibits PARP1 at the SSB site. AZD-9574 is an anticancer compound that can be used in HRD+ breast cancer and advanced solid malignancies.
M21176 Leriglitazone Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) is a PPARγ agonist that provides high transcriptional potency by stabilizing the PPARγ (AF-2) coactivator binding surface and enhancing coactivator binding capacity. Leriglitazone (Hydroxypioglitazone) binds to PPARγC (LBD) with a Ki value of 1.2 μM and induces PPARγ (LBD) transcriptional efficiency with an EC50 of 680 nM.
M21025 Balofloxacin Dihydrate an agonist of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway
M20942 Choline Fenofibrate Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.
M13724 Saroglitazar Magnesium Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.
M13723 GW1929 GW1929 is a potent PPAR-γ agonist, with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively.
M13722 15D-PGJ2 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2.
M11286 NXT629 NXT629 is an effective, selective and competitive PPAR-α antagonist. The IC50 value of HUMAN PPARα is 77 nM, which is higher than that of other nuclear hormone receptors, such as PPARδ, PPARγ, Erβ, GR and TRβ, with IC50 value of 6.0, 15, respectively. 15.2, 32.5 and >100 μM.
M11283 Inolitazone dihydrochloride Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a PPARγ agonist with high affinity, activity dependent on PPARγ, inhibiting growth, IC50 is 0.8 nM.
M11282 L-165041 L-165041 is a cell-permeable PPARδ agonist with Ki values of 6 nM for PPARδ and about 730 nM for PPARγ, which can induce adipocyte differentiation in NIH-PPARδ cells.
M11257 Alpinetin Alpinetin is a flavonoid isolated from grass cardamom, which can activate PPAR-γ and has anti-inflammatory activity.
M11255 DG172 dihydrochloride DG172 dihydrochloride is a selective PPARβ/δ antagonist with an IC50 value of 27 nM.
M10513 MA-0204 MA-0204 is a highly potent and selective PPARδ modulator (PPARδ EC50 = 0.4 nM; PPARα, EC50 = 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation.
M10453 LY518674 LY518674 is a potent and selective PPAR-alpha antagonist with EC50 of 42 nM for human PPARα.
M10245 Pemafibrate Pemafibrate is a potent and highly specific PPARα agonist, with EC50s of 1 nM, 1.10 μM and 1.58 μM for h-PPARα, h-PPARγ and h-PPARδ, respectively.
M10192 Seladelpar sodium salt Seladelpar (MBX-8025; RWJ-800025) sodium salt is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist.
M9802 EHP-101 EHP-101 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist.
M9747 Lanifibranor Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively.
M9496 Balaglitazone Balaglitazone is an agonist of peroxisome proliferator-activated receptor (PPAR) γ, with an EC50 of 1.351 μM for human PPARγ.
M9476 Elafibranor Elafibranor (also known as GFT-505) is a dual PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.



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