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Abmole Inhibitor Catalog 2017

PPAR Peroxisome Proliferator Activated Receptor


Cat.No.  Name Information
M10513 MA-0204 MA-0204 is a highly potent and selective PPARδ modulator (PPARδ EC50 = 0.4 nM; PPARα, EC50 = 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation.
M10453 LY518674 LY518674 is a potent and selective PPAR-alpha antagonist with EC50 of 42 nM for human PPARα.
M10245 Pemafibrate Pemafibrate is a potent and highly specific PPARα agonist, with EC50s of 1 nM, 1.10 μM and 1.58 μM for h-PPARα, h-PPARγ and h-PPARδ, respectively.
M10192 Seladelpar Seladelpar (MBX-8025; RWJ-800025) is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist.
M9802 EHP-101 EHP-101 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist.
M9747 Lanifibranor Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively.
M9496 Balaglitazone Balaglitazone is an agonist of peroxisome proliferator-activated receptor (PPAR) γ, with an EC50 of 1.351 μM for human PPARγ.
M9476 Elafibranor Elafibranor (also known as GFT-505) is a dual PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
M9468 SR-18292 SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression.
M9195 Saroglitazar Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity, with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.
M7584 2-Bromohexadecanoic acid 2-Bromohexadecanoic acid is a PPARδ agonist.
M6723 Fenofibrate Fenofibrate is a pPARα agonist.
M5940 Rosiglitazone HCl Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
M5927 Retinoic acid All-trans retinoic acid (ATRA; Vitamin A acid) is a metabolite of Vitamin A and a ligand of Retinoid X receptor (RXR). It is also a natural agonist of RAR nuclear receptors, with IC50 of 14 nM for RARα/β/γ.
M5878 Pioglitazone HCl Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.
M5641 Fenofibric acid Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.
M5530 Clofibrate Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.
M5171 Troglitazone (CS-045) Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth.
M4147 Astaxanthin Astaxanthin is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. *This compound is unstable in solutions, freshly prepared is recommended.
M3658 GW501516 GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.
M3635 FH535 FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
M3283 Pioglitazone Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator.
M3044 T0070907 T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM, with a >800-fold selectivity over PPARα and PPARδ.
M2748 GW9662 GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ.
M2747 GW7647 GW7647 is a potent and highly selective PPARα agonist with EC50 of 6 nM.
M2746 GW6471 GW6471 is an inhibitor of PPARα with IC50 of 0.24 μM.
M2742 GW0742 GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ.
M2732 GSK0660 GSK0660 is a selective PPARδ antagonist with IC50 of 155 nM.
M2455 Bezafibrate Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism.
M2335 ZLN005 ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator.
M2200 Ciprofibrate Ciprofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist.
M2038 Rosiglitazone maleate Rosiglitazone maleate (Avandia) is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM.
M2033 GSK 3787 GSK3787 is an orally available selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6).
M1894 Rosiglitazone Rosiglitazone is a selective ligand of peroxisome proliferator-activated receptor gamma (PPARgamma).
M1880 WY 14643 (Pirinixic Acid) WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist.
M1602 SR1664 SR1664 is an antidiabetic agent which binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation with IC50 of 80 nM and Ki of 28.67 nM.

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