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Pioglitazone HCl

Cat. No. M5878
Pioglitazone HCl Structure
Synonym:

AD-4833, U-72107E

Size Price Availability Quantity
100mg USD 52.2  USD58 In stock
500mg USD 144  USD160 In stock
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Quality Control
Biological Activity

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 392.9
Formula C19H20N2O3S.HCl
CAS Number 112529-15-4
Purity 99.46%
Solubility 69 mg/mL in DMSO
Storage at -20°C
References

Effect of pioglitazone medication on the incidence of dementia.
Heneka MT, et al. Ann Neurol. 2015 Aug;78(2):284-94. PMID: 25974006.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pioglitazone HCl, AD-4833, U-72107E supplier, PPAR, inhibitors

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