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Pioglitazone HCl

Cat. No. M5878
Pioglitazone HCl Structure
Synonym:

AD-4833, U-72107E

Size Price Availability Quantity
100mg USD 60 In stock
500mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 392.9
Formula C19H20N2O3S.HCl
CAS Number 112529-15-4
Purity >99%
Solubility 79 mg/mL in DMSO
Storage at -20°C
References

Effect of pioglitazone medication on the incidence of dementia.
Heneka MT, et al. Ann Neurol. 2015 Aug;78(2):284-94. PMID: 25974006.

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  Catalog
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Keywords: Pioglitazone HCl, AD-4833, U-72107E supplier, PPAR, inhibitors

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