Free shipping on all orders over $ 500

Rosiglitazone HCl

Cat. No. M5940
Rosiglitazone HCl Structure

BRL-49653 HCl

Size Price Availability Quantity
50mg USD 110 In stock
100mg USD 180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Product Citations
Customer Product Validations & Biological Datas
Source The FASEB Journal (2017). Figure 1. Rosiglitazone (Abmole Bioscience, Shanghai, China)
Method 3T3-L1 cell differentiation
Cell Lines 3T3-L1 cell
Concentrations 2mM
Incubation Time 3 d
Results FTO is positively regulated by PKCb. Immunoblot analyses were performed with the indicated antibodies. The quantifications of immunoblots came from 3 repeats of the experiments.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 393.89
Formula C18H19N3O3S.HCl
CAS Number 302543-62-0
Purity >98%
Solubility 79 mg/mL in DMSO
Storage at -20°C

Lack of effect of colesevelam HCl on the single-dose pharmacokinetics of aspirin, atenolol, enalapril, phenytoin, rosiglitazone, and sitagliptin.
He L, et al. Diabetes Res Clin Pract. 2014 Jun;104(3):401-9. PMID: 24721587.

Related PPAR Products

Balaglitazone is an agonist of peroxisome proliferator-activated receptor (PPAR) γ, with an EC50 of 1.351 μM for human PPARγ.


Elafibranor (also known as GFT-505) is a dual PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.


Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity, with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

Retinoic acid

All-trans retinoic acid (ATRA; Vitamin A acid) has been widely investigated for treatments of many cancers including prostate cancer.

Pioglitazone HCl

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

Abmole Inhibitor Catalog 2017

Keywords: Rosiglitazone HCl, BRL-49653 HCl supplier, PPAR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.