Free shipping on all orders over $ 500

Rosiglitazone HCl

Cat. No. M5940

Rosiglitazone HCl Structure

Synonym: BRL-49653 HCl

Size Price Availability Quantity
50mg USD 110 In stock
100mg USD 180 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Rosiglitazone HCl is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 393.89
Formula C18H19N3O3S.HCl
CAS Number 302543-62-0
Purity >99%
Solubility 79 mg/mL in DMSO
Storage at -20°C
Customer Product Validation
Source The FASEB Journal (2017). Figure 1. Rosiglitazone (Abmole Bioscience, Shanghai, China)
Method 3T3-L1 cell differentiation
Cell Lines 3T3-L1 cell
Concentrations 2mM
Incubation Time 3 d
Results FTO is positively regulated by PKCb. Immunoblot analyses were performed with the indicated antibodies. The quantifications of immunoblots came from 3 repeats of the experiments.
Rating
Product Citations
References

Lack of effect of colesevelam HCl on the single-dose pharmacokinetics of aspirin, atenolol, enalapril, phenytoin, rosiglitazone, and sitagliptin.
He L, et al. Diabetes Res Clin Pract. 2014 Jun;104(3):401-9. PMID: 24721587.

Related PPAR Products
Retinoic acid

All-trans retinoic acid (ATRA; Vitamin A acid) has been widely investigated for treatments of many cancers including prostate cancer.

Pioglitazone HCl

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

Fenofibric acid

Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

Clofibrate

Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia.

Troglitazone (CS-045)

Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Rosiglitazone HCl, BRL-49653 HCl supplier, PPAR, inhibitors

Contact Us
  • Tel: +1-800-660-8580
  • Email: sales@abmole.com
  • Tel: +32 (0)2 738 09 61
  • Email: eu.order@abmole.com

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.